Innovation

Science and technology

Medicine is becoming increasingly complex. Medical research has become a mechanism-based science involving better understanding of pathophysiology, and modelling vast amounts of data. A deeper knowledge of skin functions and development of more efficient diagnostic tests will help us fine-tune solutions that prevent skin conditions and diseases.
 

Technology creates new opportunities

Technologies from outside of medicine, such as robotics and miniaturisation, are both an opportunity and a challenge, requiring us to explore new areas and develop new skills. New technologies are revolutionising our understanding of skin and skin diseases at the molecular level, and paving the way to personalised healthcare. For example, we can now foresee being able to insert microchips into skin to measure a variety of factors, allowing us to decide on individual treatment for each patient. And there’s also a clear opportunity for us to develop new products for the skin health needs of the growing aging population.

Imaging technology

New imaging technologies allow qualitative and quantitative assessment of the effects of the potential drugs in tissues and cells. They also help us find appropriate formulations for application in humans.

Immunohistochemical (IHC) detection of cell constituents and tissue proteins is important as it allows us to understand the physiopathology of skin diseases. IHC detection in fluorescence under microscope is usually used for proteins, and a more complex detection using a multispectral microscope platform can be used for other cell constituents.

Normal skin: nuclei (DAPI Blue colorant) and epithelial cells (CK10 red colorant)
Immunofluorescence allows the detection of proteins within the skin

 

Ki67 Immunohistochemical (IHC) detection on patient with atopic dermatitis. Ki67 biomarkers are tightly associated with cell multiplication.

AD lesional skin
Atopic dermatitis lesion skin

 

Non lesional skin
Non lesional skin

 

The multispectral platform is key to strengthening our hypotheses when selecting drug targets. It enables the study of tissue sections by labelling biomarkers with fluorescent stains, and provides high-resolution images rapidly.

Multispectral analysis of inflammatory infiltrate in acne skin lesion
Multispectral analysis of inflammatory infiltrate in acne skin lesion. Normal skin: nuclei (DAPI Blue colorant) and epithelial cells (CK10 red colorant)